相关实验视频

Updated: Sep 20, 2025

Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy
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Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy

Published on: June 8, 2018

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CTC1-STN1-TEN1通过DNA末端切除阻断控制DNA断裂修复路径的选择

Cody M Rogers1, Hardeep Kaur1, Michelle L Swift2

  • 1Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Science (New York, N.Y.)
|May 22, 2025
PubMed
概括

CTC1-STN1-TEN1 (CST) 复合体通过抑制DNA末端切除来控制DNA修复路径的选择. CST功能障碍导致癌症治疗抵抗,影响DNA双链断裂 (DSB) 修复.

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