在心脏代谢疾病中解读肝心轴
Federico Capone1,2,3, Antonio Vacca1,4, Guillaume Bidault5
1Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (F.C., A.V., S.S., G.G.S.).
Circulation research
|May 22, 2025
概括
肝脏和心脏健康与心脏代谢性疾病有关. 脂肪肝和肝硬化等肝脏疾病会增加心力衰竭的风险,而心脏问题会损害肝脏.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢性疾病 代谢性疾病
背景情况:
- 肝脏和心脏紧密相连,双向通信对心脏代谢健康至关重要.
- 肝功能障碍,包括与代谢功能障碍相关的脂肪性肝病 (MAFLD),与酒精相关的肝病 (ALD) 和肝硬化,与心血管疾病 (CVD) 风险增加有关.
研究的目的:
- 审查证据,将肝功能障碍与心力衰竭和其他心血管疾病联系起来.
- 探索肝脏疾病对心脏重塑,炎症和血液动力学压力的贡献机制.
- 检查心脏功能障碍如何影响肝脏输液并导致肝脏损伤.
主要方法:
- 关于心脏代谢疾病中肝脏与心脏的相互作用的当前科学文献的综述.
- 讨论分子媒介,包括肝激素和心激素.
- 探索先进的研究方法,如omics集成,近距离标签和器官芯片平台.
主要成果:
- 肝功能障碍显著增加心力衰竭和其他心血管疾病的风险.
- 特定的肝脏疾病,如MAFLD,ALD和肝硬化促进心脏重塑,全身炎症和血液动力学压力.
- 心脏功能障碍会损害肝脏输液,加剧肝脏损伤,突出关键的器官间交声.
结论:
- 了解分子媒介和先进的研究工具对于破译肝心通信至关重要.
- 开发多器官治疗策略对于有效管理心脏代谢疾病至关重要.
- 本综述整合了机制性见解和翻译工具,以推进相互关联的肝脏和心脏疾病的治疗.
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