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Updated: Sep 20, 2025

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在小分子合物PyDH2的插曲后,四基DNAG-四重复的形状变化

Kailey N Martin1, Gwendolyn Lam1, Oksana Reznichenko2

  • 1Swarthmore College, 500 College Ave, Swarthmore, PA, 19081, USA.

Angewandte Chemie (International ed. in English)
|May 22, 2025
PubMed
概括

像PyDH2这样的小分子可以改变DNA的G-四重复 (G4) 结构. 这项研究揭示了PyDH2诱导特定的G4折叠,并插入DNA,提供治疗潜力.

关键词:
反平行椅是指一个反平行椅.它们是DNA连接体.在G-四重复合体中.间隔性 间隔性 间隔性 间隔性在X射线晶体学.

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