长期道路交通噪音,空气污染和心血管疾病 AIRCARD:一个前性队列研究
Stephan P Mayntz1, Roda A Mohamed1, Anna Mejldal2
1Cardiology Research Unit, Odense University Hospital, Svendborg, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark; OPEN - Open Patient Data Explorative Network, Odense University Hospital, Odense, Denmark.
JACC. Advances
|May 22, 2025
概括
长期暴露在道路交通噪音中显著增加了心血管疾病风险和全因死亡率. 空气污染没有显著的关联,这表明噪音的影响往往被低估.
科学领域:
- 环境健康 环境健康
- 心血管流行病学心血管流行病学
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 与空气污染和道路交通噪音等环境压力因素有关.
- 虽然已知个别影响,但对它们相对贡献的同时评估是有限的,特别是在空气污染较低的地区.
研究的目的:
- 调查长期暴露于环境空气污染和道路交通噪声与CVD之间的联系.
- 评估这些环境压力因素对心血管结果的相对贡献.
主要方法:
- 一项对26723名65-74岁男性进行的前性队列研究 (DANCAVAS和VIVA试验),具有长期污染暴露数据.
- 使用先进建模估计的住宅对空气污染物 (PM2.5,NO2,O3,SO2,CO) 和道路交通噪音 (Lden) 的暴露.
- 使用了考克斯的比例危险模型,调整了生活方式,家族史和社会经济因素. 主要不良心血管事件 (MACE) 是主要结局.
主要成果:
- 道路交通噪声增加14.9dB与MACE风险增加7.5%和所有原因死亡风险增加8.1%有关.
- 没有发现暴露于特定空气污染物的暴露与混调整后的主要或次要结果之间的显著关联.
结论:
- 长期暴露于道路交通噪声与心血管疾病风险增加和全因死亡率显著相关.
- 没有考虑噪音暴露的研究可能会高估仅归因于空气污染的心血管负担.
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