大脑结构与精细运动功能之间的关联:基于人口的莱研究的发现
Xingwang Yang1, Weiyi Zeng1, Santiago Estrada2
1Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
EBioMedicine
|May 22, 2025
概括
精细运动技能随着年龄的增长而下降,在女性中更好. 大脑结构的变化,特别是大脑总体积和运动皮层厚度的变化,与精细运动功能相关,特别是追踪精度.
科学领域:
- 神经科学是一个神经科学.
- 人类解剖学 人类解剖学
- 老年学是一门学科.
背景情况:
- 以前的研究表明,脑缩和精细运动功能之间存在不一致的关联.
- 在一个大队伍中,研究了精细运动技能和与年龄/性别相关的大脑结构变化之间的联系.
研究的目的:
- 为了确定是否下降的精细运动功能与与年龄和性别相关的大脑结构变化相关.
- 探索成年人一生中特定的精细运动技能和大脑形态之间的关系.
主要方法:
- 在以人口为基础的莱研究中,利用了来自8318名参与者 (30-95岁) 的横截面数据.
- 通过数字螺旋绘图测试评估精细运动技能 (跟踪精度,速度,震动频率).
- 从3T T1MRI扫描中分析了大脑体积和皮质厚度的测量,并对共变量进行了多变量回归调整.
主要成果:
- 较小的总大脑体积和较薄的前中心环皮层与跟踪精度降低和震增加有关.
- 降低海马体积与跟踪精度降低相关.
- 较低的追踪速度与较小的小脑和小脑灰质总体体积有关.
- 女性表现出更好的精细运动功能,但与年龄相关的变化与性别没有差异.
结论:
- 老年人的精细运动功能受损,女性的精细运动功能受损.
- 大脑结构,包括总大脑体积和运动皮层厚度,与精细运动功能显著相关,特别是追踪精度.
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