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Updated: Sep 20, 2025

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
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A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG

Published on: March 7, 2017

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含有CBX4的特定形式的cPRC1被选择为在扩散的中线质瘤中调解瘤基因抑制

Eimear Lagan1, Dáire Gannon2, Ademar Jesus Silva2

  • 1Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer University of Edinburgh, Edinburgh, UK; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK.

Molecular cell
|May 22, 2025
PubMed
概括

研究人员确定了一种特定的PRC1复合体 (CBX4/PCGF4),对扩散中线质瘤 (DMG) 的生长至关重要. 这个复合体驱动瘤基因抑制,为这种致命的儿童大脑癌症提供了新的治疗点.

关键词:
这就是CBX4 CBX4.在 EZH2 中使用.H3K27M 在线播放H3K27me3 在线阅读在PCGF4中,在PRC1中,在 PRC2 中,PRC2 是 PRC2 的第一个类型.聚合的多元.扩散性内皮性庞丁性质瘤扩散的中线质瘤

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