甲基生成与微生物改变短链脂肪酸的产生和人类宿主代谢的能量相关
Blake Dirks1,2, Taylor L Davis1,2, Elvis A Carnero3
1Biodesign Center for Health through Microbiomes, Arizona State University, Tempe, AZ 85287, United States.
The ISME journal
|May 22, 2025
概括
甲生物,即产生甲的微生物,与增加宿主能量吸收有关. 这发生在通过从纤维中增强短链脂肪酸 (SCFA) 的产生,特别是在高纤维饮食中.
科学领域:
- 微生物学 微生物学
- 人类的新陈代谢.
- 我们的肠道微生物组.
背景情况:
- 甲生物是消耗气并产生甲的古生物.
- 之前的研究不一致地将甲原体与肥胖联系起来.
- 甲基生物可以通过改变肠道水平和发酵来影响宿主代谢.
研究的目的:
- 为了研究甲基生物,其他类植物和人类代谢能源 (ME) 之间的关系.
- 探索甲基生成如何影响短链脂肪酸 (SCFA) 生产和从饮食中提取能量.
主要方法:
- 随机交叉养研究与西方和高纤维饮食.
- 在参与者身上持续测量甲.
- 分析性的丰富度,SCFA水平 (便和血清),以及宿主ME.
主要成果:
- 大约一半的参与者体内都存在甲基生物.
- 高甲生产者显示血清酸盐和酸盐路径中的活性增加.
- 高甲生产者在高纤维饮食中患有更高的ME,这与纤维降解细菌有关.
结论:
- 微生物联盟中的甲基生成与宿主ME的增加有关.
- 增强的SCFA生产和宿主吸收有助于这种联系.
- 甲基生物在食物链中发挥作用,从未消化的基质中提取能量.
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