相关实验视频

Updated: Jun 13, 2025

Establishing a Device for Sleep Deprivation in Mice

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

腹部体区域的功能连接性作为适应睡眠剥夺的弹性标记

Jungwon Cha¹, Kathryn E R Kennedy¹, David Negelspach¹

¹Social, Cognitive, & Affective Neuroscience Laboratory, Department of Psychiatry, University of Arizona, 1501 N. Campbell Avenue, Tucson, AZ 85724, USA.

Neuroscience letters

|May 22, 2025

概括

对睡眠不足有弹性的个体,在腹膜区域 (VTA) 和视觉/认知控制区域之间显示出更强大的大脑连接. 这种VTA连接有助于在延长的清醒期间保持认知表现.

科学领域:

神经科学是一个神经科学.
认知科学认知科学
睡眠研究睡眠研究

背景情况:

睡眠不足 (SD) 显著损害认知功能,包括注意力和反应速度.
对SD认知效应的恢复能力的个体差异表明存在潜在的神经生物学变异.
腹膜区域 (VTA) 涉及到奖励和兴奋,可能在认知性中发挥作用.

研究的目的:

调查睡眠剥夺对认知性的神经生物学基础.
检查VTA功能连接和SD下的认知表现之间的关系.
识别特定的大脑区域,其与VTA的连接可能会赋予弹性.

主要方法:

44名健康的成年人接受了休息状态功能性MRI (rs-fMRI) 评估静脉动脉连接.
参与者完成了28小时的睡眠剥夺协议.
使用心理运动警觉测试 (PVT) 测量认知表现,量化百分比反应速度变化 (PRSC).

主要成果:

更高的PRSC,表明更大的弹性,与VTA功能连接性增加有关.
具体来说,更强的VTA与主要视觉皮质 (V1) 和补充和眼场 (SCEF) 的连接与SD下更好的认知表现相关.
这些发现表明,与视觉和认知控制区域的VTA连接对于在睡眠剥夺期间保持表现至关重要.

结论:

在睡眠剥夺期间,VTA在认知性中发挥着关键作用.
静脉动脉和视觉/认知控制区域 (V1,SCEF) 之间的连接是支持SD下保存认知功能的重要神经机制.
了解这些神经机制为我们提供了在具有挑战性的条件下保持认知表现的见解.

关键词:

认知性认知性功能连接性的功能连接性.这是一个PVTPVT.睡眠不足的原因是睡眠不足.在VTA中,VTA是VTA.功能磁力共振成像 (fMRI) 是一种

更多相关视频

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

相关概念视频

Insufficient Sleep and Sleep Deprivation

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...

Understanding Sleep

Understanding Sleep

Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...