血清和尿液中氧化代谢物与脂肪肝指数之间的关联:基于人口的研究
Zahra Bahadoran1, Fereidoun Azizi2, Asghar Ghasemi3
1Micronutrient Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nitric oxide : biology and chemistry
|May 22, 2025
概括
较高的尿氧化代谢物 (NOx) 水平,反映了饮食中酸盐摄入量,与患非酒精性脂肪肝疾病 (NAFLD) 的可能性较低有关. 这表明饮食中酸盐可能有助于肝脏健康.
科学领域:
- 代谢学 代谢学 代谢学
- 营养生物化学 营养生物化学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的健康问题.
- 脂肪肝指数 (FLI) 作为NAFLD和肝硬化症的非侵入性标志物.
- 氧化 (NO) 在新陈代谢调节中发挥作用,但其与NAFLD的关联需要进一步研究.
研究的目的:
- 检查血清和尿液中氧化物代谢物 (NOx) 水平和脂肪肝指数 (FLI) 之间的关系.
- 为了确定NOx与肌素 (Cr) 的比率是否与NAFLD的患病率有关.
主要方法:
- 来自德黑兰脂质和葡萄糖研究 (2015-2017) 的598名成年人的横截面研究.
- 使用格里斯反应量化血清和尿液NOx.
- 使用已确定的临床参数计算FLI.
- 后勤回归分析以评估NOx与Cr比率与NAFLD (FLI≥60) 之间的关联.
主要成果:
- 在参与者中,NAFLD的患病率为32.4%.
- 在血清NOx-to-Cr比率和NAFLD之间没有发现显著的关联.
- 尿中NOx-to-Cr比率较高 (第二和第三次) 与NAFLD的概率降低显著相关.
结论:
- 增加尿中的NOx-to-Cr比率,表明饮食中酸盐摄入量较高,与NAFLD风险较低有关.
- 食中酸盐可能在维持肝脏健康方面发挥保护作用.
- 尿液中NOx与Cr的比率可以作为饮食中酸盐摄入量及其对NAFLD风险的影响的潜在生物标志物.
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