在严重喘中,唾液细胞性和MRI通风缺陷.
Hana Serajeddini1, Ashutosh Thakar1, Melanie Kjarsgaard1
1Firestone Institute for Respiratory Health, St. Joseph's Healthcare Hamilton, Department of Medicine, McMaster University, Hamilton, ON, Canada; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
严重喘患者在所有唾液细胞表型中表现出异常的呼吸道通风. 波西格兰细胞性喘通风缺陷可能源于粘液,与更高的排气氧化水平有关.
科学领域:
- 肺部医学 肺部医学
- 医疗成像医学成像
- 免疫学 免疫学 免疫学
背景情况:
- 气道炎症,标志着埃索诺菲尔或中性粒细胞,是喘的核心.
- 虽然唾液中的埃索诺菲尔与通风缺陷相关,但其他细胞类型的影响尚不清楚.
研究的目的:
- 通过使用129XeMRI在重症喘患者中研究明显的唾液细胞表型和异常呼吸道通风之间的关系.
主要方法:
- 85名严重喘患者和15名对照患者接受了129Xe呼吸MRI.
- 唾液细胞测量将喘患者分为平粒细胞类,eosinophilic,neutrophilic和混合粒细胞类的表型.
- 排气缺陷百分比 (VDP) 被量化并与表型和对照进行了比较.
主要成果:
- 异常通气 (VDP升高) 观察到44%的Paucigranulocytic,64%的eosinophilic,75%的中性爱和89%的混合-granulocytic喘表型.
- 与对照人群相比,患有异性,中性和混合表型的喘患者的VDP显著更高 (P < .0001).
- 患有异常通风的Paucigranulocytic喘患者年龄较大,呼吸氧化和CT粘液分数较高.
结论:
- 在严重的喘中,内细胞炎症与异常的呼吸道通风有关,无论特定的细胞表型如何.
- 气道粘液和高分量的排气氧化可能导致Paucigranulocytic喘的通风异常.
更多相关视频
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