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Updated: Jun 13, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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对选择性,共价的JNK2/3抑制剂的"联体先"方法

Valentin R Wydra1, Nicole Plank2, Stefan Zwirner3

  • 1Department of Pharmaceutical/Medicinal Chemistry, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, DE, Germany.

Journal of medicinal chemistry
|May 22, 2025
PubMed
概括

研究人员开发了新的JNK2/3选择性抑制剂. 这些化合物,无论是可逆的还是共价的,都显示出高强度和细胞活性,而共价化合物显示出出色的动力和选择性概况.

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