胆汁盐通过边缘激活作用触发了脂质体囊中的可变性.
1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) - Raebareli, Lucknow, (Uttar Pradesh) 226002, India.
Molecular pharmaceutics
|May 22, 2025
概括
胆盐,如脱氧化 (NaDC),增强脂质体的机械特性和可变性. 这提高了它们穿越生物障碍的潜力,为药物输送提供了新的可能性.
科学领域:
- 生物化学 生物化学
- 材料科学 材料科学 材料科学
- 物理化学 物理化学
背景情况:
- 脂质体是重要的药物输送载体.
- 调节脂质体的机械特性是增强生物屏障透的关键.
- 已知胆汁盐与脂质双层相互作用.
研究的目的:
- 调查基于胆盐的边缘激活剂 (EA) 对脂质体机械特性和可变性的影响.
- 为了阐明特定胆盐 (胆酸盐,NaC;脱氧酸盐,NaDC;陶酸盐,NaTC) 对由l-α-酸胆 (SPC) 组成的脂质体的影响.
主要方法:
- 通过薄膜水化进行脂质体配方.
- 使用散射,光谱和原子力显微镜 (AFM) 进行表征.
- 强力变形和强力缩实验,以评估机械性能.
主要成果:
- 胆盐改变了脂质体的水力动力直径,形态和机械特性.
- 变形性和扬模是按照 NaDC ≥ NaC > NaTC 的顺序进行的.
- 富里埃转换红外光谱 (FTIR) 证实了疏水性相互作用和增强的结合,增加了胆盐度.
结论:
- 脱氧酸 (NaDC) 显著改善了脂质体的机械特性和可变性.
- 通过NaDC观察到增强的脂质体弹性和降低的Young模量.
- 这些发现表明,在药物输送应用中,可以提高生物屏障透的潜力.
更多相关视频
12:18Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
Published on: August 3, 2021
3.7K
07:49Spontaneous Formation and Rearrangement of Artificial Lipid Nanotube Networks as a Bottom-Up Model for Endoplasmic Reticulum
Published on: January 22, 2019
8.0K
相关概念视频
Mechanisms of Membrane-bending
2.9K
The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
2.9K
Asymmetric Lipid Bilayer
7.9K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
7.9K
Assembly of the Lipid Bilayer in the ER
3.4K
Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
3.4K
Lipid Digestion
94.2K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
94.2K
Receptor-mediated Endocytosis
106.2K
Overview
106.2K
Lipid Absorption
868
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
868
