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根据法医解剖结果,一个致命的托塞米德滥用病例

Akina Nara¹, Chiho Yamada¹, Yu Kozakai¹

¹Division of Legal Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai-shi, Japan.

Journal of forensic sciences

|May 23, 2025

概括

这项研究报告了第一个死因于长期滥用循环利尿剂torsemide的尸检案例. 慢性滥用可以导致伪巴特特综合征,导致致命的结果,强调需要使用处方.

科学领域:

毒理学毒理学毒理学
腎臟病學 (nephrology) 是一種醫學專業.
法医病理学法医病理学

背景情况:

循环利尿剂,如托塞米德治疗心力衰竭患者的胀.
滥用减肥或掩盖物质是令人担忧的.
慢性滥用可以导致低血,功能障碍 (伪巴特特综合征) 和死亡.

研究的目的:

报告第一个死因是由于torsemide滥用的尸检案例.
在致命病例中详细说明解剖结果和毒理学分析.
为了强调不适当的循环利尿剂使用的危险.

主要方法:

对已故患者进行解剖和组织病理学检查.
血清尿素和肌水平分析.
超高性能液体染色学-双重质谱仪用于血液中的托塞米德量化.

主要成果:

尸体解剖显示了与伪巴特综合征相一致的脏变化.
观察到血清肌素和血尿素水平升高.
毒理学分析证实Torsemide在心脏血液中的致命度.

结论:

死亡原因被确定为长期滥用托尔塞米德的中毒.
这一案例强调了与非处方循环利尿剂使用相关的风险.
循环利尿剂应严格在医疗监督下使用.

关键词:

在 LCMS/MS 中使用.奎瑟人奎瑟人法医毒理学法医毒理学循环利尿剂循环利尿剂这就是Torsemide.

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