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相关概念视频

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

174
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
174
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Types of Toxins01:36

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Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
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Irritable Bowel Syndrome I: Introduction01:17

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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中链甲改变了神经行为和诱导神经炎症,与肠道平衡障碍相关.

Luyao Zhang1, Danyang Zhang1, Bufan Xu1

  • 1School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.

Journal of agricultural and food chemistry
|May 23, 2025
PubMed
概括

中链化抛 (MCCPs) 暴露在动物模型中引起神经炎症和异常行为. 此外,MCCP还破坏了肠道微生物群,并促进了肠道炎症,这表明通过微生物群-肠道-大脑轴的联系.

关键词:
肠道菌群是指肠道上的植物.中链化石墨烯中链化石墨烯微生物肠大脑轴神经炎症是一种神经炎症.短链脂肪酸 短链脂肪酸

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科学领域:

  • 环境毒理学环境毒理学
  • 神经科学是一个神经科学.
  • 微生物学 微生物学

背景情况:

  • 甲 (CPs) 是工业化学品,由于对短链甲 (SCCPs) 的限制,中链甲 (MCCPs) 的使用越来越多.
  • 在食品和动物大脑中检测到MCCP,引发了对潜在健康风险的担忧.
  • MCCP对肠道平衡和神经系统的影响在很大程度上是未知的.

研究的目的:

  • 为了研究MCCP暴露的神经行为,神经和胃肠道影响.
  • 阐明肠道微生物及其代谢物在MCCP诱导的毒性中的作用.
  • 通过微生物群-肠道-大脑轴评估MCCP的潜在风险.

主要方法:

  • 动物模型暴露于CP-52,一种流行的MCCP.
  • 评估了神经行为变化,大脑组织病理学 (灰质厚度,星球细胞激活) 和神经炎症标志物.
  • 分析了肠道微生物群的组成,短链脂肪酸 (SCFA) 水平和肠道炎症.

主要成果:

  • 暴露于CP-52导致异常行为,灰质厚度降低,星球细胞激活和神经炎症.
  • 观察到肠道微生物群组成的显著变化.
  • 检测到SCFA水平降低和肠道炎症增加,可能将肠道失调与神经炎症联系起来.

结论:

  • 暴露于MCCP对神经系统和肠道平衡都有风险.
  • 肠道微生物群-肠道-大脑轴可能会调解MCCP诱导的神经炎症.
  • 调查结果突出了在食品和环境背景下对MCCP的安全评估的需要.