中链甲改变了神经行为和诱导神经炎症,与肠道平衡障碍相关
Luyao Zhang1, Danyang Zhang1, Bufan Xu1
1School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Journal of agricultural and food chemistry
|May 23, 2025
概括
中链化抛 (MCCPs) 暴露在动物模型中引起神经炎症和异常行为. 此外,MCCP还破坏了肠道微生物群,并促进了肠道炎症,这表明通过微生物群-肠道-大脑轴的联系.
科学领域:
- 环境毒理学环境毒理学
- 神经科学是一个神经科学.
- 微生物学 微生物学
背景情况:
- 甲 (CPs) 是工业化学品,由于对短链甲 (SCCPs) 的限制,中链甲 (MCCPs) 的使用越来越多.
- 在食品和动物大脑中检测到MCCP,引发了对潜在健康风险的担忧.
- MCCP对肠道平衡和神经系统的影响在很大程度上是未知的.
研究的目的:
- 为了研究MCCP暴露的神经行为,神经和胃肠道影响.
- 阐明肠道微生物及其代谢物在MCCP诱导的毒性中的作用.
- 通过微生物群-肠道-大脑轴评估MCCP的潜在风险.
主要方法:
- 动物模型暴露于CP-52,一种流行的MCCP.
- 评估了神经行为变化,大脑组织病理学 (灰质厚度,星球细胞激活) 和神经炎症标志物.
- 分析了肠道微生物群的组成,短链脂肪酸 (SCFA) 水平和肠道炎症.
主要成果:
- 暴露于CP-52导致异常行为,灰质厚度降低,星球细胞激活和神经炎症.
- 观察到肠道微生物群组成的显著变化.
- 检测到SCFA水平降低和肠道炎症增加,可能将肠道失调与神经炎症联系起来.
结论:
- 暴露于MCCP对神经系统和肠道平衡都有风险.
- 肠道微生物群-肠道-大脑轴可能会调解MCCP诱导的神经炎症.
- 调查结果突出了在食品和环境背景下对MCCP的安全评估的需要.
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