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Updated: Sep 20, 2025

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
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Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells

Published on: August 12, 2015

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通过氨酸甲基转移酶SET8对BRCA1信号的细胞循环依赖抑制

Yannick Perez1,2, Fatima Alhourani1,2, Julie Patouillard1

  • 1Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Institut Régional du Cancer (ICM), Montpellier, France.

Cell cycle (Georgetown, Tex.)
|May 23, 2025
PubMed
概括

甲基转移酶SET8通过将BRCA1锁定在染色质上来抑制同源重组 (HR). 它在S阶段的降解对于DNA修复复合体的积累至关重要,它在细胞周期调节的DNA修复中发挥了重要作用.

关键词:
53BP1BP1是什么意思这就是BRCA1的原因.DNA修复和染色质的修复甲基化 H4K20 甲基化在SET8中,SET8是SET8.

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