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辅助生殖技术和后代恶性瘤的风险:一个元分析

Linyu Zhang^1,2, Gang Tang³, Xinrui Sun^1,2

¹Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.

International journal of surgery (London, England)

|May 23, 2025

概括

辅助生殖技术 (ART) 不会增加后代的恶性瘤总体风险. 然而,ART可能与特定癌症 (如白血病和各种瘤) 的更高风险有关.

科学领域:

生殖医学生殖医学
儿科瘤学儿科瘤学
流行病学流行病学

背景情况:

在全球范围内,辅助生殖技术 (ART) 的使用正在增加.
人们对通过ART怀孕的儿童潜在的长期健康风险,包括恶性瘤存在担忧.
以前对ART和后代癌症风险的研究产生了有争议的结果.

研究的目的:

系统评估辅助生殖技术 (ART) 与后代恶性瘤风险之间的关联.
综合来自多项研究的证据,以澄清ART与儿童癌症之间的有争议的关系.

主要方法:

在主要数据库 (Embase,科学网,PubMed,Cochrane图书馆) 进行了系统的文献搜索.
分析了来自20个队列和4个病例控制研究的数据.
计算了几率比率 (OR) 和95%置信区间来评估恶性瘤风险.

主要成果:

与自然怀孕相比,通过ART怀孕的后代的恶性瘤总体风险没有显著增加 (OR,1.04).
亚组分析显示ART组中白血病 (OR,1.24) 软组织瘤 (OR,1.35),肝脏瘤 (OR,2.10) 和上皮瘤/黑色素瘤 (OR,1.50) 的风险增加.
对于淋巴瘤,视网膜母细胞瘤,中枢神经系统瘤,神经母细胞瘤,脏瘤,生殖细胞/阴茎瘤和胚胎瘤的风险没有显著差异.

结论:

辅助生殖技术 (ART) 与后代整体恶性瘤的风险增加无关.
在ART和特定癌症的高风险之间存在潜在的关联,包括白血病,软组织瘤,肝脏瘤,上皮瘤和黑色素瘤.

关键词:

辅助生殖技术是一种辅助生殖技术.在冷胚胎转移过程中,在体外受精体外受精.细胞体内精子注射细胞体内精子注射儿科的恶性瘤.

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