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Updated: Sep 20, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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通过核氨酸和小热冲击蛋白复合体调节MDM2-p53连接

Jeong Hyo Lee, Mo Chen, Tianmu Wen

    bioRxiv : the preprint server for biology
    |May 23, 2025
    PubMed
    概括

    基因毒性压力激活了PIPKIα,产生了与MDM2.2结合的PIP2. 这种相互作用调节了MDM2的稳定性及其与p53的相互作用,为癌症治疗提供了新的策略.

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