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在肌肉侵入性膀癌中新辅助化疗前后的PD-L1和Ki-67表达

Daichi Sasaki¹, Tohru Yoneyama², Fumiya Yoneyama¹

¹Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

International journal of urology : official journal of the Japanese Urological Association

|May 23, 2025

概括

新辅助化疗 (NAC) 显著增加了编程细胞死亡配体1 (PD-L1) 的表达,并降低了肌肉侵入性膀癌 (MIBC) 的Ki-67标记指数. 需要进一步的研究来了解基因表达的变化如何影响预后.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
膀癌研究膀癌研究

背景情况:

编程细胞死亡连接体1 (PD-L1) 是肌肉侵入性膀癌 (MIBC) 的预后不良因素.
在新辅助化疗 (NAC) 后对PD-L1表达变化的数据有限.

研究的目的:

在MIBC患者中,在NAC前后研究PD-L1和Ki-67表达之间的纵向关联.
探索后NAC的差异性基因表达变化.

主要方法:

对104名MIBC患者进行了以为基础的NAC和激进囊切除术的回顾性分析.
分析了经尿道切除 (TURBT) 和化疗后残留疾病 (RC) 的匹配瘤样本.
对PD-L1和Ki-67进行了免疫组织化学和基因表达概况分析.

主要成果:

在NAC后,PD-L1阳性显著增加 (15.4%至28.8%).
中位数Ki-67标签指数在NAC后显著下降 (30.6%至9.9%).
治疗效果和基因表达变化之间的相关性很难确定.

结论:

在MIBC中,NAC显著影响PD-L1表达和Ki-67指数.
后NAC基因表达改变的预后意义需要进一步调查.

关键词:

这就是 Ki-67 的特点.在PD-L1中.膀癌:膀癌是一种癌症.囊切除术 (cystectomy) 是一种切除囊的方法.预后预后预后

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