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Updated: Sep 20, 2025

Visualization of Endoplasmic Reticulum Subdomains in Cultured Cells
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Published on: February 18, 2014

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细胞内膜网膜应激诱导GRP78的液体-液体相分离,并调节蛋白质聚合动态.

Jiaqi Li1,2, Xiangyu Zi1, Jiabao Fang1

  • 1School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 1 Wenyuan Road, Nanjing, Jiangsu 210023, China.

ACS sensors
|May 23, 2025
PubMed
概括

葡萄糖调节蛋白78 (GRP78) 在细胞应激下形成凝结物,招募与疾病相关的蛋白质,如SOD1 (A4V). 这种液-液相分离 (LLPS) 影响蛋白质聚合,为神经退行性疾病机制提供了洞察力.

关键词:
细胞内膜网膜的压力应激光终身成像成像 光终身成像液态 - 液态相隔离的方法极性的灵敏度 极性的灵敏度蛋白质聚合蛋白质的聚合物

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