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年龄和任务需求之间的相互作用与口相关的大脑连接性.

Chia-Shu Lin1,2,3,4, Wei-Chieh Kao1

  • 1Department of Dentistry, National Yang Ming Chiao Tung University, Taipei City, Taiwan.

Journal of oral rehabilitation
|May 23, 2025
PubMed
概括
此摘要是机器生成的。

与能力相关的大脑连接随着年龄和任务难度的变化而发生变化. 具有更好的能力的老年人显示在感觉运动区域的连接更强,而年轻人则在苛刻的任务中参与该区域之外的网络.

关键词:
年龄化的衰老.大脑大脑大脑的大脑大脑消化 消化 消化 消化静止状态的功能连接性任务需求任务需求

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科学领域:

  • 神经科学是一个神经科学.
  • 老年学是一门学科.
  • 生物医学工程 生物医学工程

背景情况:

  • 感官运动处理对于老年大脑和老年人的健康至关重要.
  • 功能 (MP) 显著影响老年人的整体健康.
  • 研究表明,大脑功能连接 (FC) 和MP之间存在联系.

研究的目的:

  • 调查与功率 (MP) 相关的功能连接 (FC).
  • 为了检查任务需求和年龄如何影响食期间大脑的功能连接.
  • 使用干扰任务 (MPT) 探索这些关系.

主要方法:

  • 招募了三个年龄组的参与者:年轻人 (YA,<40),中年人 (MA,40-64),老年人 (OA,≥65).
  • 进行了结构性和静止状态 (rs) 功能性MRI (fMRI) 扫描.
  • 在基线和扰乱的MPT条件下分析了基于种子的连接和FC网络.

主要成果:

  • 在OA中更好的MP与小脑和感觉运动皮层 (基线) 之间的更高的rs-FC相关.
  • 在扰乱中,在OA中更好的MP与更高的rs-FC (中额前-体感皮质) 相关,在MA中与 (补充运动区域-尾状核) 相关.
  • 与MP相关的rs-FC模式因年龄和任务条件而异,YA在扰乱期间显示在传感运动网络之外的rs-FC增加.

结论:

  • 年龄和任务需求互动地影响与功能的休息状态功能连接 (rs-FC).
  • 这些发现突出了动态的神经适应,支持整个生命周期的食.
  • 为老年人感官运动控制和大脑健康提供了新的见解.