炎症性肌肉病和心肌炎是自然猫咪免疫缺陷病毒感染的相关并发症
Francesco Prisco1,2,3, Emanuela Vaccaro1, Lorena Cardillo4
1Unit of Pathology, Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Naples, Italy.
Veterinary pathology
|May 23, 2025
概括
猫中自然发生的猫类免疫缺陷病毒 (FIV) 感染经常与炎症性肌肉病和心肌炎有关. 这种由T细胞驱动的炎症,具有潜在的自身免疫参与,会影响猫的肌肉和心脏组织.
科学领域:
- 兽医病理学 兽医病理学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 炎症性肌肉病 (IM) 和心肌炎是人类免疫缺陷病毒 (HIV) 感染的已知并发症.
- 猫的猫免疫缺陷病毒 (FIV) 感染可以导致类似的炎症状况,正如实验研究表明的那样.
研究的目的:
- 调查自然感染FIV猫的IM和心肌炎的流行情况.
- 在这些条件下描述炎症过程及其病原体.
- 为了确定潜在的自身免疫机制.
主要方法:
- 组织学和免疫组织化学检查FIV感染和对照猫的骨肌肉和心肌样本.
- 在白细胞中检测FIV-p24-gag抗原.
- 定量逆转录PCR (qRT-PCR) 用于炎症媒介基因转录.
- 对抗骨肌肉自身抗体的间接免疫光 (IIF) 试验.
主要成果:
- 在FIV感染猫的骨肌肉35%和心肌样本37%中发现了炎症透物.
- 炎症透细胞中T细胞占主导地位,一些白细胞含有FIV-p24-gag.gag.
- 感染FIV的猫表现出炎症媒介 (IFN-γ,TNF-α,IL-17,TGF-β,IL-13) 的基因转录变化以及抗骨肌肉自身抗体的存在.
结论:
- 自然发生的FIV感染经常与IM和心肌炎有关.
- 这种炎症是由T细胞驱动的,具有Th1/Th17极化.
- 循环中的抗肌肉自身抗体表明,在与FIV相关的IM和心肌炎中,自身免疫病原发生.
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