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PELI1静音延迟了椎间盘退化,因为它阻碍了细胞核的细胞死亡

Xiaodong Wei1, Chao Yu1, Jingjie Wang1

  • 1The Second Department of Spine Surgery, Yantaishan Hospital, Yantai, Shandong, China.

Connective tissue research
|May 23, 2025
PubMed
概括

佩利诺E3无素蛋白联酶1 (PELI1) 通过增加细胞死亡和NLRP3炎症酶驱动的炎症,促进椎间盘退化 (IDD). 沉默PELI1可能为IDD提供治疗策略.

关键词:
椎间盘退化 椎间盘退化在NLRP3炎症酶体中,NLRP3炎症在PELI1的基础上,PELI1细胞衰老 细胞衰老细胞外矩阵退化 细胞外矩阵退化

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