在接受乳腺手术的患者中,对鼻腔黄金葡萄球菌的监测
Ma Jesús Pérez-Granda1,2,3,4, Andrés Visedo1,2, Martín Olivares5
1Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
近30%的乳腺手术患者在鼻子中携带金黄色葡萄球菌. 聚合酶链反应 (PCR) 是最好的查方法,但需要进一步研究脱殖,以预防感染.
科学领域:
- 传染性疾病 传染性疾病
- 手术部位感染 手术部位感染
- 微生物学 微生物学
背景情况:
- 黄金葡萄球菌感染通过查和脱殖,主要是在骨科和心脏手术中减少.
- 乳房外科手术,尽管被归类为干净的,但存在感染的风险.
- 黄金菌的鼻腔携带是手术部位感染的潜在来源.
研究的目的:
- 在接受乳腺手术的患者中评估黄金葡萄球菌鼻腔携带的频率.
- 为了比较培养和PCR分析在检测S. aureus鼻腔定居的有效性.
- 确定S. aureus鼻腔携带作为乳腺手术后感染风险因素的作用.
主要方法:
- 在高等教学医院进行了长达10个月的前性观察研究.
- 包括100名接受乳房重建手术的患者.
- 在手术前采集鼻子拭子,通过培养和Xpert MRSA/SA SSTI PCR测定进行分析.
主要成果:
- 27%的患者被确定为S. aureus的鼻腔携带者.
- 在27名患者中,PCR检测检测到S. aureus殖民,而培养物检测到20名患者.
- 两名手术前有S. aureus鼻携带的患者在手术后出现了感染.
结论:
- 乳腺手术患者中很大一部分是S. aureus的鼻腔携带者.
- 与培养相比,PCR测定是识别S. aureus鼻携带的优越诊断策略.
- 进一步研究鼻腔和乳头脱殖战略是有必要的,以减少感染率和并发症.
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