在COVID-19后2年内肠道菌群的纵向变化及其与肺部序列的相关性
Qianhan Xie1, Jiali Ni1, Ling Yu1
1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
COVID-19幸存者在两年内表现出显著的肠道菌群变化,影响肺功能恢复. 特定的真菌变化与肺功能相关,为长期COVID综合征提供了洞察力.
科学领域:
- 微生物学 微生物学
- 肺部病理学 肺部病理学
- 胃肠病学 胃肠病学
背景情况:
- 肺部连续病是COVID-19后日益令人担忧的一个问题.
- 肠道失调症与急性后COVID-19综合征有关,但肠道菌群的作用尚不清楚.
研究的目的:
- 为了研究COVID-19后肠道菌群的纵向变化.
- 在两年内将肠道菌群组成与肺功能恢复联系起来.
- 探索肠道菌群作为诊断标记物和急性后COVID-19的治疗点.
主要方法:
- 在46名COVID-19患者和37名对照组的前性研究中.
- 在多个时间点通过ITS 3-4测序进行纵向肠道菌群评估.
- 在2年后的肺功能测试和CT扫描与真菌生物群数据相关联.
主要成果:
- 肠道真菌丰富度在放出后6个月内正常化.
- 特定的真菌属 (例如,Hanseniaspora,Saturnispora) 与肺功能参数 (PEF,DLCO) 在2年内相关.
- 丰富的Pichia,Saccharomycopsis和Cladosporium与没有CT异常有关.
结论:
- 肠道菌群在COVID-19后经历了显著的纵向变化.
- 肠道菌群组成与肺功能恢复有关,这表明它在长期COVID病变发生过程中发挥了作用.
- 肠道菌群可能作为后急性COVID-19综合征和潜在治疗点的生物标志物.
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