7βHuh7

Andreas Betz1, Hao-En Huang1, Zuguang Gu2,3

  • 1Department of Infectious Diseases, Molecular Virology, Section Virus-host interactions, Heidelberg University, Heidelberg, Germany.

Journal of virology
|May 23, 2025
PubMed
概括

像Huh7这样的肝瘤细胞因缺少干扰素调节因子7 (IRF7) 而与干扰素生产作斗争. 在这些细胞中恢复IRF7可以改善它们的天生的免疫反应,使它们成为研究病毒性肝炎的更好的模型.

相关概念视频

Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.