SXT/R391元素ICEPmiJpn1与其天然宿主Proteus mirabilis的相互作用
Douglas Lyra de Holanda Fonseca1, Gaby Soares Scheunemann1, Bruna Nakanishi Fortes1
1Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Microbiology spectrum
|May 23, 2025
概括
像ICEPmiJpn1这样的整合和结合元素 (ICE) 不会伤害它们的宿主细菌Proteus mirabilis,但它们的传播取决于细菌菌株因素. 这项研究澄清了ICE-宿主相互作用和抗生素耐药性基因流动性.
科学领域:
- 微生物学 微生物学
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 整合性和结合性元素 (ICE) 是可传播抗菌素耐药性基因的移动遗传元素.
- SXT/R391家族的ICE广泛分布,并集成到细菌染色体中.
- 了解宿主-细菌关系对于控制抗生素耐药性至关重要.
研究的目的:
- 调查ICEPmiJpn1与其自然宿主Proteus mirabilis之间的关系.
- 评估ICEPmiJpn1对P.奇迹虫生理学和致病性的影响.
- 为了确定P. mirabilis遗传背景如何影响ICE转移.
主要方法:
- 使用的同源P.奇迹菌株 (有或没有ICEPmiJpn1).
- 评估了细菌的适应性,自我识别,蜂群,病原性,持久性和生物膜形成.
- 进行了交配测试,以研究使用不同的P. mirabilis捐赠者对大肠杆菌的结合性转移.
主要成果:
- ICEPmiJpn1并没有显著影响P. mirabilis的健康状况,自我识别,蜂群,病原性或持久性.
- 生物膜的形成在一种P.奇迹菌株中增加,该菌株含有ICEPmiJpn1.1.
- ICEPmiJpn1的结合转移效率因P. mirabilis供体菌株而异.
结论:
- ICEPmiJpn1与P. mirabilis呈现稳定的关联,没有表现出不良的生理或病原性影响.
- ICE转移受到元素特异性监管者和宿主菌株特异性因素的影响.
- 需要对宿主依赖机制进行进一步的研究,以打击抗生素耐药性的传播.
关键词:
ICEPmiJpn1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1n1ICEs是什么意思多国企业 (MGE) 是一个多国企业.这种动物是Proteus mirabilis.在SXT/R391上.生物膜是一种生物膜.结合方式 结合方式健身 健身 健身 健身 健身 健身它是持久的,持续的.蜂拥而至,如一群人.更多相关视频
09:26Identification of Antibacterial Immunity Proteins in Escherichia coli using MALDI-TOF-TOF-MS/MS and Top-Down Proteomic Analysis
Published on: May 23, 2021
3.3K
07:59Extraction and Visualization of Protein Aggregates after Treatment of Escherichia coli with a Proteotoxic Stressor
Published on: June 29, 2021
3.7K
相关概念视频
01:25Microbial Interactions: Mutualism
80
Mutualism is a symbiotic interaction in which all participating organisms benefit. These relationships can be obligate or facultative and are fundamental to ecosystem functions across diverse biological systems.Plant–Fungi MutualismOne well-known example is the association between plant roots and mycorrhizal fungi, such as Rhizophagus species. The fungal hyphae penetrate the root hairs and the epidermis, forming an extensive hyphal network that establishes a symbiotic association. Through...
80
01:26Microbial Interactions: Cooperation
59
Microbial cooperation involves beneficial interactions in which different species work together for individual or mutual advantage. These interactions can profoundly influence ecological dynamics and evolutionary processes, and they are essential to many pathogenic and symbiotic relationships.Nematode–Bacteria CooperationA striking example is the relationship between the Gram-negative bacterium Xenorhabdus nematophila and the parasitic nematode Steinernema carpocapsae. Juvenile nematodes...
59
01:28Microbial Interactions: Predation
65
Microbial predation refers to the process by which one microorganism kills and consumes another to obtain nutrients and energy. It encompasses both bacterial and protozoan predators. This interaction plays a crucial role in shaping microbial communities and regulating nutrient cycling.Bacterial Predators: Epibiotic vs. EndobioticBacterial predators are classified based on their mode of attack as either epibiotic or endobiotic. Epibiotic predators, such as Vampirococcus, attach to the surface of...
65
01:26Microbial Interactions: Competition
87
Microbial competition is an ecological interaction in which microorganisms vie for limited resources within shared environments. These resources may include nutrients, space, or light, depending on the system. The intensity and outcome of competition are influenced by the environmental context, such as nutrient availability, spatial constraints, and the diversity of microbial species present. These competitive interactions significantly influence the structure, function, and resilience of...
87
01:09Microbe-Plant Interactions
140
Microbe-plant interactions represent a dynamic spectrum of associations shaped by intricate chemical signaling. These interactions can be neutral, beneficial, or detrimental, and profoundly influence plant physiology, growth, and ecosystem function. The plant microbiome, comprising bacteria, fungi, archaea, protists, and viruses, plays a pivotal role in mediating these effects through surface colonization, internal colonization, or systemic symbiosis.Mutualistic associations, particularly with...
140
01:24iChip
105
The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
105