在为期10天的多压力实地训练期间,氧化应激调节和谷氨系统反应
Liāna Pļaviņa1,2, Edgars Edelmers3
1Department of Morphology, Rīga Stradiņš University, LV-1010 Riga, Latvia.
Journal of functional morphology and kinesiology
|May 23, 2025
概括
这项研究发现,10天的军事实地课程,尽管有强烈的身体和睡眠需求,改善了学员的抗氧化剂状态. 训练增强了谷氨的防御能力,并减少了氧化应激标志物,而不会造成DNA或肌肉损伤.
科学领域:
- 运动生理学 运动生理学
- 氧化压力研究研究 氧化压力研究
- 军事医学 军事医学
背景情况:
- 军事训练课程强加显著的身体,心理情绪,热量和睡眠剥夺压力.
- 了解这种多重压力环境对氧化/抗氧化状态的影响,对于士兵的健康和表现至关重要.
- 核酸和骨肌损伤的生物标志物是生理应变的关键指标.
研究的目的:
- 评估为期10天的多重压力现场培训课程对全身氧化和抗氧化状态的影响.
- 为了评估核酸和骨肌损伤生物标志物的变化,在训练有素的军事学员中.
- 为了研究长时间多重压力暴露的适应性反应.
主要方法:
- 75名健康的军事学员 (8名女性,67名男性) 接受了为期10天的实地课程,强制限制卡路里摄入量 (700-800卡路里/天) 和睡眠限制 (两次20分钟的午睡/24小时).
- 血生物标志物,包括超氧化物脱酶 (SOD),谷氨 (GSH,GSSG),甲 (MDA),过氧化 (H2O2),8-基-2-脱氧氨酸 (8-OHdG) 和肌球蛋白在疗程前和后被测量.
- 计算了氧化应激指数 (OSI);统计分析包括威尔科克森签名等级测试和斯皮尔曼相关性.
主要成果:
- 训练后观察到减少的谷氨 (GSH,+175%) 和氧化谷氨 (GSSG,+32%) 的显著增加.
- 与此同时,SOD (-19%),H2O2 (-20%),MDA (-50%),8-OHdG (-23%),和OSI (-47%) 的显著下降也被注意到.
- 肌球蛋白水平保持不变,相关性表明一种由谷氨驱动的适应性应对氧化应激反应.
结论:
- 十天的强烈,受限制的实地训练在身体准备好的学员中引起了有利的氧化还原适应.
- 适应的特点是增强的谷氨介导抗氧化能力和减少循环氧化剂度.
- 没有发现DNA或骨肌损伤的证据,这表明长时间的多重压力暴露可以加强内源性抗氧化防御.
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