温度差异与中国兰州慢性阻塞性肺病急性恶化之间的关联
Hongran Ma1, Furong Qu1, Jiyuan Dong2
1School of Public Health, Lanzhou University, Lanzhou, 730000, People's Republic of China.
低温,高日间温度范围 (DTR) 和相邻天之间的低温度变化 (TCN) 增加了慢性阻塞性肺病 (AECOPD) 门诊病例急性恶化的风险. 老年男性特别容易受到这些温度变化的影响.
科学领域:
- 环境流行病学环境流行病学
- 肺部医学 肺部医学
- 生物统计学 生物统计学
背景情况:
- 慢性阻塞性肺病 (AECOPD) 的急性恶化是医疗保健利用的重要原因.
- 温度变化越来越多地被认为是呼吸系统疾病的环境风险因素.
- 了解不同温度指标对AECOPD的具体影响对于公共卫生干预至关重要.
研究的目的:
- 调查温度差异 (邻近天 (TCN) 和昼间温度范围 (DTR) 之间的温度变化) 与AECOPD门诊访问之间的关联.
- 将这些关联按性别和年龄分层.
- 确定易受温度相关AECOPD恶化影响的弱势群体.
主要方法:
- 利用分布式滞后非线性模型 (DLNM) 来分析温度指标和AECOPD访问之间的关系.
- 分析了邻近日 (TCN) 和日间温度范围 (DTR) 之间的温度变化作为关键暴露变量.
- 对性别 (男性/女性) 和年龄 (<65,65-74,≥75岁) 进行了分层分析.
主要成果:
- 低环境温度与AECOPD访问的最高相对风险 (RR) 相关 (RR=1.175在滞后0).
- 极高的日间温度范围 (DTR) 与AECOPD访问的10天延迟 (RR=1.017) 有显著的关联.
- 邻近日间的低温变化 (TCN) 也增加了AECOPD风险,其中最显著的单日效应是滞后0 (RR=1.051).
- 老年男性 (≥75岁) 与其他群体相比,对低温,低TCN和高DTR的敏感性更高.
结论:
- 暴露于低温,高DTR和低TCN与AECOPD门诊访问的风险增加有关.
- 患有AECOPD的患者应对温度波动采取预防措施.
- 弱势群体,特别是老年男性,需要有针对性的公共卫生考虑和保护策略.
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