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相关概念视频

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

110
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
84
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

89
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
89
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

64
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
64
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

108
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
108
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

62
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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慢性病在常见变性免疫缺陷中的慢性病:一个多中心研究

Chiara De Renzis1, Renato Finco Gambier2, Antonietta Gigante1

  • 1Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy.

Journal of clinical immunology
|May 23, 2025
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概括

慢性病 (CKD) 影响超过6%的常见可变免疫缺陷 (CVID) 的成年人. 自身免疫性细胞衰退是这些患者中CKD的关键风险因素,强调需要对功能进行监测.

关键词:
衰老的衰老 衰老的衰老慢性脏疾病 慢性脏疾病常见的变量免疫缺陷.调节失调是一种失调.炎症 炎症是一种炎症.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 腎臟病學 (nephrology) 是一種醫學專業.
  • 内部医学 内部医学

背景情况:

  • 常见可变免疫缺陷 (CVID) 是一种主要免疫缺陷,其特征是B细胞分化和抗体产生受损.
  • 在CVID中,脏参与很少被报告,并且通常归因于感染,炎症或治疗副作用.

研究的目的:

  • 为了确定慢性病 (CKD) 在成年CVID患者中的患病率.
  • 确定与CVID中CKD发展相关的临床,实验室和治疗因素.

主要方法:

  • 一项多中心的观察性回顾性研究,涉及来自意大利五个转诊中心的367名成年CVID患者.
  • 分析包括患者人口统计,并发病,传染性和非传染性表现,实验室数据和治疗方案.

主要成果:

  • 在6.27%的CVID患者中诊断出CKD,这些患者年龄较大,患高血压,糖尿病和脂质失调率较高.
  • 患有CKD的患者表现出明显的超声波异常,COPD的频率更高,淋巴细胞和B细胞数量较低.
  • 在CVID患者中,自身免疫性细胞衰竭与CKD独立相关,同时具有较高的中性粒细胞与淋巴细胞的比率,并使用三甲胺-硫胺醇预防药物.

结论:

  • 在CVID中CKD的患病率受到衰老,并发症,免疫失调和炎症的影响.
  • 建议对所有CVID患者进行定期功能评估,特别是那些具有显著炎症负担的患者.