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哺乳与心血管疾病的长期风险之间的关联
Christine Field1, William A Grobman, Jiqiang Wu
1Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio; the Department of Obstetrics and Gynecology, Brown University, Providence, Rhode Island; the Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin; and the Departments of Preventive Medicine, Medicine, and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
哺乳与降低长期动脉样硬化心血管疾病 (ASCVD) 风险有关,特别是在以前患有妊娠糖尿病 (GDM) 的人群中. 这强调了母乳养.
科学领域:
- 心血管健康 心血管健康
- 母婴健康 母婴健康
- 流行病学 流行病学
背景情况:
- 动脉样性心血管疾病 (ASCVD) 是全球主要的死亡原因.
- 孕期糖尿病 (GDM) 是未来母亲ASCVD的已知危险因素.
- 哺乳对健康的长期影响,特别是关于有经历GDM的母亲的心血管结果,需要进一步调查.
研究的目的:
- 为了确定母乳养是否与长期ASCVD风险降低有关.
- 调查这种关联是否受到妊娠糖尿病 (GDM) 病史的改变.
主要方法:
- 预期高血糖和不良妊娠结果 (HAPO) 后续研究的二次分析.
- 暴露:任何母乳养 (是/不是).
- 结果:估计ASCVD风险 (10年和30年) 使用弗雷明汉风险评分,评估10-14年产后. 多变量线性回归调整为共变量. 研究了GDM状态对效果的修改.
主要成果:
- 哺乳与估计较低的10年ASCVD风险 (调整后β-0.13) 和30年ASCVD风险 (调整后β-0.36) 相关.
- 哺乳对ASCVD的保护性关联在有史以来GDM的个体中明显更强,而不是没有.
- 对GDM状态的相互作用P值为10年ASCVD风险的0.004和30年ASCVD风险的0.003.
结论:
- 哺乳与降低动脉样硬化心血管疾病的长期风险有关.
- 这种保护作用在有妊娠期糖尿病史的妇女中尤为明显.
- 促进母乳养可能是改善女性,特别是患有GDM的女性长期心血管健康的有益策略.
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