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系统性硬化症患者的身体成分是否重要?

Chiara Giraudo1, Giulia Fichera1, Marco Binda2

  • 1Unit of Advanced Clinical and Translational Imaging, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Padova University Hospital, Padova, Italy.

Rheumatology (Oxford, England)
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概括

身体构成显著影响硬化皮肤病 (SSc) 患者的治疗结果. 骨髓炎和低肌肉质量预测死亡率,强调在SSc管理中需要对身体组成进行评估.

关键词:
这就是为什么CTCTCTCTCT这就是为什么SSc SSc身体构成 身体组成影像成像技术 影像成像技术

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科学领域:

  • 类风湿病学 类风湿病学
  • 肺部病理学 肺部病理学
  • 放射学 放射学是指放射学
  • 身体组成分析 身体成分分析

背景情况:

  • 身体组成,包括肌肉质量和脂肪组织,越来越多地被认为在风湿和自身炎症性疾病中的作用.
  • 硬化皮质 (SSc) 是一种复杂的自身免疫性疾病,具有显著的系统影响,其中身体组成因素可能会影响疾病的进展和患者的结果.

研究的目的:

  • 评估肌肉质量和皮下脂肪组织质量和数量的对系统性硬化症 (SSc) 患者死亡率的影响.
  • 确定身体组成指标作为SSc患者死亡率的预测指标.

主要方法:

  • 包括接受高分辨率胸部CT (HRCT) 的成年SSc患者.
  • 半自动细分用于分析第12个背脊椎的皮下脂肪和椎肌肉,量化面积和密度.
  • 使用逐步线性回归和概率风险比率来评估死亡率的预测因素,包括骨髓炎 (肌肉脂肪透).

主要成果:

  • 肺部对一氧化碳 (DLCO) 的扩散能力较低,BMI较高,皮下脂肪密度增加,骨肌肉指数较低预测SSc患者的死亡率.
  • 在SSc患者中,相当一部分 (72%) 呈现肌肉骨病 (肌肉脂肪透).
  • 肌肉脂肪透与3345倍高的死亡风险有关.

结论:

  • 系统性硬化症患者经常出现骨髓炎和sarcopenia前期.
  • 身体组成参数,特别是肌肉质量和数量,似乎显著影响SSc.的整体预后和生存时间.