客观,但不是主观,白天的嗜睡预测了阻塞性睡眠呼吸暂停的死亡率
Yanyuan Dai1,2,3, Alexandros N Vgontzas4, Baixin Chen1,2,3
1Department of Sleep Medicine, Shantou University Mental Health Center, Shantou University Medical College, Shantou, Guangdong, People's Republic of China.
Sleep
|May 23, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 与客观的过度白天嗜睡 (EDS) 显著增加死亡风险. 在OSA患者中,主观EDS与死亡率没有类似的关联,突出了客观EDS作为关键健康指标.
科学领域:
- 睡眠医学 睡眠医学
- 心血管健康 心血管健康
- 公共卫生 公共卫生
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与心血管疾病有关.
- 过度白天嗜睡 (EDS) 是一种常见的OSA症状,但其与死亡率的关联需要澄清.
- 客观和主观EDS之间的区别可能会影响预后意义.
研究的目的:
- 调查阻塞性睡眠呼吸暂停 (OSA) 与客观或主观的过度白天嗜睡 (EDS) 和一般人群中的死亡率之间的联系.
- 确定在OSA患者中客观EDS或主观EDS是否影响所有原因和心血管疾病 (CVD) 死亡率.
主要方法:
- 追溯队列研究包括244名OSA患者和553名对照.
- 随访时间中位数为8年.
- 通过多重睡眠延迟测试 (MSLT) 定义的客观EDS延迟时间≤8分钟;根据爱普沃思睡眠度量表 (ESS) 获得的主观EDS得分>10.
主要成果:
- 经过调整后的分析显示,具有客观EDS的OSA与所有原因死亡率的2.5倍高风险和心血管疾病死亡率的3.9倍高风险有关.
- 具有客观EDS和基线心血管疾病的OSA患者有2.9倍的全因死亡风险.
- 有主观EDS的OSA与所有原因或心血管疾病死亡率没有显著关联.
结论:
- 目标EDS是OSA生物严重性的关键标志物.
- 结果表明客观EDS,而不是主观EDS,与OSA患者的死亡率增加有关.
- 需要在不同人群中进行进一步的验证和干预研究.
相关概念视频
Sleep Apnea
484
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
484
Insufficient Sleep and Sleep Deprivation
840
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
840
Sleep-Wake Cycles
2.7K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
2.7K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
354
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
354
Substance Use Disorders Affecting Sleep
403
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
403
Narcolepsy
505
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
505


