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Updated: Jan 18, 2026

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人类祖先群体中高度有害变异的分布

Anastasia Stolyarova1, Graham Coop2, Molly Przeworski1,3

  • 1Department of Biological Sciences, Columbia University, New York, NY 10027.

Proceedings of the National Academy of Sciences of the United States of America
|May 23, 2025
PubMed
概括

严重疾病突变通常在进化上很年轻,在所有人类祖先中以相似的速度发现. 测序更多的个体,无论祖先,是识别这些关键遗传变异的关键.

关键词:
祖先的血统 祖先的祖先人类遗传学人类遗传学功能丧失突变的突变变化选择平衡的变化病原性变体的病原性变体

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