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纳米复合材料在3D打印药物输送系统中的潜在应用
Marwan Algellay1, Satyajit D Sarker2, Matthew Roberts1
1School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, United Kingdom.
The Journal of pharmacy and pharmacology
|May 23, 2025
概括
纳米材料通过提高机械强度,可溶性和药物释放来增强3D打印制药剂量形式. 本综述探讨了它们在先进药物输送系统中的应用.
科学领域:
- 材料科学 材料科学 材料科学
- 制药技术 制药技术 制药技术
- 生物医学工程 生物医学工程
背景情况:
- 增材制造,或3D打印 (3DP),是多功能,用于创建各种材料的物体.
- 3DP越来越多地被用于制药剂量形式和药物输送系统.
- 纳米材料具有独特的特性,可以增强3D打印制药.
研究的目的:
- 审查纳米材料在生物聚合物矩阵中的应用,用于3D打印.
- 探索这些纳米复合材料在制药剂量形式中的潜力.
- 为3D打印药物输送系统的进步提供视角.
主要方法:
- 审查现有的关于3D打印技术的文献 (立体石墨,FDM,选择性激光烧结,生物打印).
- 对将纳米材料 (纳米颗粒,纳米晶体,微丝带) 纳入聚合物的研究进行分析.
- 评估纳米材料对3D打印药物输送系统性能的影响.
主要成果:
- 纳米材料显著改变了3DP中使用的聚合物的机械和流量特性.
- 药物装载的纳米囊在3D打印的平板电脑中模块化药物释放配置文件.
- 加入奇托桑微条带改善了FDM 3DP.的丝特性.
- 在3D打印的药丸中的柏柏林纳米粒子增强了药物释放和吸收.
- 纳米晶体提高了3D打印口腔膜的可溶性.
结论:
- 纳米复合材料对于改进3D打印药物输送系统至关重要.
- 关键的改进包括增强的机械强度,可溶性和受控的药物释放.
- 这种方法对先进的制药应用具有重大前景.
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