相关实验视频
Updated: Jun 12, 2025

04:44
Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
222
使用数字表型来区分单极性抑郁症和双极性障碍:系统审查
Rongrong Zhong1, XiaoHui Wu1, Jun Chen1
1Clinical Research Center & Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Journal of medical Internet research
|May 23, 2025
概括
通过分析活动模式和语音,数字表型显示在区分双相情感障碍 (BD) 和单相情感抑郁症 (UD) 中具有前景. 需要进一步的研究来解决临床使用的隐私和访问挑战.
科学领域:
- 数字健康数字健康
- 心理健康技术 心理健康技术
- 计算精神病学是一种计算精神病学.
背景情况:
- 由于预后和治疗方法不同,区分双相情感障碍 (BD) 和单相情感抑郁症 (UD) 非常重要.
- 数字表型化利用来自数字设备的数据,为心理健康评估提供了一种新的方法.
- 本综述侧重于数字表型化在区分BD和UD方面的作用.
研究的目的:
- 系统地审查关于数字表型的文献,以区分UD和BD.
- 通过使用数字表型识别对UD,BD和健康对照 (HC) 进行分类的研究进行审查.
- 确定研究缺口,并建议该领域的未来方向.
主要方法:
- 在多个数据库 (Scopus,PubMed等) 中进行系统搜索. 在2025年3月20日之前.
- 包括使用便携式/可穿戴式数字工具进行UD/BD区分或分类的原始研究.
- 排除不基于专业医疗评估或仅依赖EHR/临床数据的评论和研究.
主要成果:
- 包括21项研究,其中11项区分UD/BD,10项分类UD/BD/HC.
- 智能手机应用程序和可穿戴设备分析了活动水平,BD患者表现出较低的活动和与UD患者不同的日常模式.
- 视听录音和多式联络方法,特别是语音,提高了UD,BD和HC组的分类准确性.
结论:
- 数字表型化证明了区分BD与UD的潜力.
- 关键的挑战包括数据隐私,安全和确保公平访问.
- 未来的研究应该专注于克服这些障碍,以提高临床适用性.
相关概念视频
Bipolar Disorder
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Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
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Depression: Overview
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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Depressive Disorders: Etiology
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Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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Antidepressant Drugs: MAOIs and Other Agents
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Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
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Diagnostic and Statistical Manual of Mental Disorders (DSM)
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The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
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Depressive Disorders: MDD and Dysthymia
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Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
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