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基于皮质类固醇的联合治疗对突然聋的影响:一项回顾性研究
Liang'e Zhi1, Shiyuan Li2, Yajin Feng3
1Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of the Army Medical University, Chongqing 400038, China; Department of Otolaryngology-Head and Neck Surgery, Qionglai Medical Center Hospital, Sichuan 611500, China.
在7天内及较年轻年龄 (<18岁) 的早期治疗可以改善突然失聪的结果. 组合疗法,特别是高压氧气疗法,不能改善听力恢复.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经学 神经学
- 听力学 听力学是指听力学.
背景情况:
- 系统性皮质类固醇是急性聋 (SD) 的第一线治疗.
- 影响SD治疗结果和组合疗法疗效的因素尚不清楚.
- 这项研究调查了SD治疗成功的预测因素.
研究的目的:
- 评估治疗开始时间和患者年龄对SD结局的影响.
- 评估组合疗法的疗效,包括高压氧气疗法 (HBOT),巴托克索宾和针.
- 为了确定治疗不响应者中的治疗性内皮质类固醇 (ICT) 的有效性.
主要方法:
- 对248名SD患者接受基于皮质类固醇的组合治疗的分析.
- 将患者分为四个亚型的分类.
- 评估听力改善和症状缓解 (头,耳).
主要成果:
- 早期治疗 (≤7天) 和年轻年龄 (<18岁) 与更好的结果显著相关 (P <0.05).
- 巴托克索宾和针对治疗结果没有显著影响 (P > 0.05).
- 高压氧化疗 (HBOT) 与全耳聋和低频下降亚型 (P <0.05) 的听力改善更差有关.
结论:
- 强调早期治疗 (≤7天) 突发性聋,特别是在年轻患者.
- 组合疗法,特别是HBOT,并不能改善SD的预后.
- 补救性静脉内皮质类固醇 (ICT) 对SD患者提供了进一步的益处,这些患者患有完全聋,对初始全身疗法反应不佳.
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