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Updated: Sep 20, 2025

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使用scRNA-Seq数据对基因调控网络的建模,推断和评估方法过程的调查

José Eduardo H da Silva1, Heder S Bernardino1, Itamar L de Oliveira1

  • 1Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, s/n, Juiz de Fora, 36036-900, Minas Gerais, Brazil.

Bio Systems
|May 23, 2025
PubMed
概括

单细胞RNA测序 (scRNA-Seq) 为基因调控网络 (GRN) 分析提供了高分辨率,但面临着挑战. 这项研究强调了影响GRN推断准确性的数据预处理和评估指标方面的问题.

关键词:
GRN 方法的方法论.基因监管网络 基因监管网络网络评估 网络评估网络推断网络推断.这就是 scRNA-Seqq.

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RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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