与神经管闭合障碍相关的定期交替的食otropia
James R Lewis1, Andrew H Malem2, J Raymond Buncic3
1Department of Ophthalmology, Royal Alexandra Hospital Regional, Edmonton, Alberta, Canada.
概括
这项研究确定了患有神经管缺陷和水脑的儿童的周期性交替食热症 (PAE). PAE,通常伴有凝视和头部转动,表明在这个人群中存在着独特的临床实体.
科学领域:
- 眼科医生 眼科 眼科
- 儿科神经学 儿科神经学
- 神经科学是一个神经科学.
背景情况:
- 周期性交替性食热症 (PAE) 是一种影响眼睛运动的罕见疾病.
- 神经管缺陷 (NTD) 和水头是严重的先天性疾病.
- PAE与这些神经疾病之间的关联需要进一步调查.
研究的目的:
- 描述了一系列儿科患者呈现周期性交替食热症 (PAE).
- 为了调查PAE与神经管缺陷和水头的同时发生.
- 描述受影响儿童的眼动力和神经特征.
主要方法:
- 在20年的时间里,对PAE患者的医疗记录进行了回顾性审查.
- 详细分析眼动力特征和相关的神经病理.
- 包括以前发表的案例进行全面审查.
主要成果:
- 确定了五名患有PAE的儿科患者.
- 所有患者都表现出PAE与定期交替的凝视 (PAG) 和逆向的头转.
- 患者患有先天性神经管缺陷和水头,需要早期的腹腔关节突变插入.
结论:
- 这些发现表明,在患有NTD和脑水性疾病的儿童中,眼动异常存在着一致的模式.
- 周期性交替性食热症 (PAE) 与头部转相结合,可能代表这个患者群体中的特定临床实体.
- 建议在患有神经管缺陷和相关头部转的患者考虑PAE.
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