米提取物减轻成人抑郁症状的疗效:一项随机,双盲,安慰剂对照试验
Sung-Young Huh1, Ye Li Lee2, Su Hui Kim3
1Department of Psychiatry, Pusan National University Yangsan Hospital and Department of Psychiatry, Pusan National University School of Medicine, Yangsan, Republic of Korea.
The American journal of clinical nutrition
|May 23, 2025
概括
在8周内,大米提取物补充剂 (RBS) 在患有轻度至中度抑郁症的成年人中显著降低了抑郁症状. 这种天然补充剂有望改善情绪和幸福感.
科学领域:
- 营养神经科学 营养神经科学
- 心理药理学 心理药理学
- 综合医学是一个整体医学.
背景情况:
- 临床前研究表明,大米提取物补充剂 (RBS) 可能减轻抑郁症状.
- 轻度至中度抑郁症影响了相当一部分成年人群,需要探索新的治疗途径.
研究的目的:
- 评估8周服用大米提取物补充剂 (RBS) 的成年人经历轻度至中度抑郁症状的疗效和安全性.
- 评估RBS对各种情绪和焦虑量表的影响,以及与抑郁症相关的关键生物标志物.
主要方法:
- 一项随机,双盲,安慰剂对照试验,涉及100名患有轻度至中度抑郁症的成年人 (韩国版汉密尔顿抑郁评分表 (K-HDRS) 分数为7-24).
- 参与者每天服用1克RBS或安慰剂8周,评估包括K-HDRS,贝克抑郁症目录II,患者健康问卷-9 (K-PHQ-9),贝克焦虑目录 (K-BAI) 和生物标志物分析.
- 生物标志物包括血清大脑衍生的神经营养因子,血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清.
主要成果:
- 与安慰剂组相比,RBS组的K-HDRS得分显著减少 (P < 0.001).
- 在RBS组的K-BDI-II和K-BAI分数中观察到更大的改善趋势.
- 在治疗后的RBS组中,K-PHQ-9分数明显较低 (P = 0.026). 在其他生物标志物中没有发现显著差异,也没有报告任何不良事件.
结论:
- 米提取物补充剂 (RBS) 在缓解轻度至中度严重的成年人抑郁症状方面似乎有效.
- RBS代表了一种潜在的有益和安全的自然干预,用于管理抑郁症状.
- 进一步的研究可能会探索RBS在心理健康中的具体机制和更广泛的应用.
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