开发和试点测试一个成诊所为基础的暴露前预防,吸收和坚持干预的药物使用障碍妇女的成诊所:试点随机试验的协议
Angela M Heads1, Diane Santa Maria2, Mandy J Hill1
1McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States.
JMIR research protocols
|May 23, 2025
概括
这项研究开发了一种基于成诊所的干预措施,以增加在有物质使用障碍 (SUD) 的种族和少数民族妇女中使用暴露前预防 (PrEP). 该干预措施旨在通过改善这种脆弱人群的PrEP吸收和坚持来减少艾滋病毒差异.
科学领域:
- 公共卫生 公共卫生
- 预防艾滋病毒 预防艾滋病毒
- 药物使用障碍 药物使用障碍
背景情况:
- 黑人和西班牙裔妇女面临着不成比例的高艾滋病毒传播率,通常与物质使用障碍 (SUDs) 相关.
- 暴露前预防 (PrEP) 是有效的,但被少数族裔妇女使用SUDs.
- 需要文化相关的干预措施来增加这些女性的PrEP吸收和坚持.
研究的目的:
- 评估基于成诊所的综合行为和PrEP服务干预措施的有效性,可行性和可接受性.
- 增加有SUD的种族或少数民族妇女的PrEP吸收和坚持.
主要方法:
- 一个三阶段混合方法设计:定性形成性研究,试点测试和试点随机对照试验 (RCT).
- 试点RCT将随机选择60名女性接受标准SUD治疗或综合SUD治疗与PrEP服务.
- 干预包括动机咨询和移动健康应用程序,以支持PrEP启动和遵守.
主要成果:
- 定性发现为干预设计提供了信息.
- 试点RCT的招聘始于2024年5月.
- 统计分析正在等待研究完成.
结论:
- 基于成诊所的干预措施针对SUD和相关风险行为妇女的艾滋病毒预防.
- 这种干预措施有可能减少黑人和西班牙裔妇女在艾滋病毒相关的健康差异.
- 研究结果将为SUD的少数民族妇女未来的艾滋病毒预防策略提供信息.
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