Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Introduction to Fibroblasts01:09

Introduction to Fibroblasts

3.2K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
3.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Real-world treatment patterns and determinants of therapy in systemic sclerosis: findings from the German Network for SSc cohort.

Arthritis research & therapy·2026
Same author

Exploring Variation in Infants' Preference for Infant-directed Speech: Evidence From a Multi-Site Study in Africa.

Developmental science·2026
Same author

A data-driven, weighted flare score that accurately predicts organ damage in systemic lupus erythematosus.

Annals of the rheumatic diseases·2026
Same author

Fibroblast Mitochondrial Ca<sup>2+</sup> Overload Drives Skin Fibrosis via Mitochondrial DNA Leakage and Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Activation in Systemic Sclerosis.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Real-World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity-Matched Study From the EUSTAR Cohort.

Arthritis care & research·2026
Same author

What 5000 babies can tell us about developing minds and how to study them.

Communications psychology·2026

相关实验视频

Updated: Sep 20, 2025

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch
07:51

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch

Published on: December 10, 2020

5.7K

空间多组学解读了系统性硬化症中的纤维细胞-巨细胞动态.

Zhijian Li1, Aleix Rius Rigau2, Wenjie Xie3

  • 1Broad Institute of MIT and Harvard, Cambridge, MA, USA; Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.

Annals of the rheumatic diseases
|May 23, 2025
PubMed
概括

系统性硬化症 (SSc) 涉及纤维细胞和巨细胞在纤维细胞中的相互作用. 准CXCR4显示有可能减少SSc中的纤维化,提供新的治疗途径.

更多相关视频

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
05:42

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

1.2K
Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
09:18

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

8.6K

相关实验视频

Last Updated: Sep 20, 2025

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch
07:51

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch

Published on: December 10, 2020

5.7K
Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
05:42

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

1.2K
Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
09:18

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

8.6K

科学领域:

  • 结合组织疾病 结合组织疾病
  • 免疫学 免疫学 免疫学
  • 基因组学就是基因组学.

背景情况:

  • 干细胞-免疫细胞相互作用在全身性硬化症 (SSc) 发病过程中至关重要.
  • 在SSc中驱动纤维生成的空间组织和通信网络仍然不完全理解.

研究的目的:

  • 研究SSc皮肤中的组织组织和细胞协调.
  • 为了获得关于SSc疾病机制的时空洞察力.
  • 为了弥合OMIC数据和SSc.的精准医学之间的差距.

主要方法:

  • 在SSc和对照皮肤活检上进行空间转录 (10×Visium和Stereo-seq).
  • 空间蛋白质组学和单细胞RNA测序.
  • 在SSc模型中的体内和体内验证研究.

主要成果:

  • 在SSc中鉴定了扩展的纤维细胞,富含纤维细胞和巨细胞,与疾病严重程度相关.
  • 描述了特定疾病的纤维细胞和巨细胞状态及其空间相互作用.
  • 发现ACKR3在调节巨细胞招募中的作用,并证明CXCR4抑制在实验模型中减少纤维化.

结论:

  • 一个空间分辨的地图表揭示了动态的纤维细胞-巨细胞相互作用,驱动SSc.中的纤维细胞利基扩张.
  • 这些发现为SSc病变发生提供了时空洞察力.
  • 该研究为SSc的先进机制和治疗策略奠定了基础.