在左乳房质子治疗计划中,相对生物有效性加权的剂量节约使用线性能量转移优化函数来优化左乳房质子治疗计划中面临风险的器官
Bobby R Waldrip1, Mahnoor Malik2, Paula Paez2
1Medical Dosimetry Program, University of Wisconsin, La Crosse, WI, USA; University of Florida Health Proton Therapy Institute, Jacksonville, FL, USA.
概括
优化质子疗法的优化
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
背景情况:
- 质子疗法的恒定相对生物效率 (RBE) 为1.1可能低估了风险器官 (OAR) 剂量,这是由于远距离光束端的高线性能量转移 (LET) 导致的.
- 左乳房笔光束扫描 (PBS) 治疗与前部领域对心脏和肺部的风险构成高LET.
- 为了节省OAR,LET优化RBE加权剂量 (D_vRBE) 在治疗规划中未得到充分研究.
研究的目的:
- 评估LET优化在减少OAR剂量的有效性.
- 为了实现>10%的心脏,双侧肺和部关节的平均或最大D_vRBE的减少.
- 在LET优化过程中确保充分的目标覆盖.
主要方法:
- 对12例左侧局部先进的侵袭性乳腺癌病例的回顾性分析.
- 在 LET 优化的 PBS 计划和临床接受的 PBS 计划之间比较 OAR 剂量.
- 使用Wilcoxon-Signed Rank测试进行统计分析.
主要成果:
- 显著降低了心脏和心侧肺的平均D_vRBE (p < 0.05).
- 在关节最大D_vRBE显著降低 (p < 0.05).
- 观察到最大和平均LET在psilateral肺部的减少 (p <0.05).
结论:
- LET优化有效降低左乳PBS治疗中OAR的D_vRBE.
- 这一策略有可能将OAR毒性降到最低.
- 对LET优化的进一步研究对于改善质子治疗结果至关重要.
相关概念视频
02:59Biological Effects of Radiation
17.6K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
17.6K
01:17Radiation: Applications
1.7K
The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
The average...
1.7K