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Updated: Sep 20, 2025

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癌症相关的KCNQ1功能丧失突变增强了Wnt/β-catenin信号,破坏了表皮平衡

Camille Berenguier1, Xingyu Chen2, Benoit Allegrini1

  • 1iBV, Université Côte d'azur, CNRS, Inserm, Nice, France.

Oncogene
|May 23, 2025
PubMed
概括

在KCNQ1通道中的功能丧失突变破坏了上皮癌信号传递. 这些突变通过绕过正常受体和抑制抑制剂来激活Wnt/β-catenin通路,从而影响组织平衡.

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