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Simone Elder¹, Laura K Kaizer², Mary D Sammel²

¹Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. simone.elder@cuanschutz.edu.

Journal of assisted reproduction and genetics

|May 23, 2025

概括

对于计划的卵细胞冷保存,仅释放性腺激素激素激素激素 (GnRHa-only) 触发剂导致较高的卵细胞产量和成熟率,而不是双重触发剂,特别是那些高剂量的HCG.

科学领域:

生殖内分泌学生殖内分泌学
在体外受精过程中受精.
卵细胞冷保存方法

背景情况:

卵细胞冷保存是保持生育能力的关键策略.
触发最终卵细胞成熟对于成功的冷保存至关重要.
计划卵细胞冷保存的最佳触发策略仍在争论中.

研究的目的:

为了比较仅释放性腺激素激素激素激素激剂 (GnRHa-only) 触发和双触发协议之间的卵细胞产量和成熟率.
在双触发协议中评估不同剂量人类胆性淋巴激素 (HCG) 的影响.
评估在接受计划性卵子冷保存且生育能力不明的个体中这些结果.

主要方法:

1002个计划的卵细胞冷保存周期 (2010-2023) 的回顾性队列研究.
患者接受了单独的GnRHa触发剂或双重触发剂 (GnRH-a与HCG1500-10,000 IU).
分析的关键结果:检索的卵子总数,成熟的卵子和成熟率,经过对共变量进行调整.

主要成果:

与所有双触发组相比,仅GnRHa触发组的产量显著更多的卵细胞被检索出来 (p < 0.02).
使用10,000 IU的HCG与仅使用GnRHa触发器的双触发器的成熟率降低了10% (RR=0.9,p=0.003).
较低HCG剂量 (1500-5000 IU) 的双触发器比高剂量的HCG双触发器检索更多的卵细胞,但成熟率相似.

结论:

与双重触发剂相比,仅GnRHa触发剂在计划的卵细胞冷保存中与更高的卵细胞产量和成熟率有关.
在双触发器中高剂量的HCG可能会降低卵细胞成熟度.
建议进行前性研究,以证实这些发现并减轻偏见.

关键词:

这是一个双触发器.保存生育能力保护生育能力释放淋巴激素激素的激素激素触发者乐普罗立德乙酸盐的使用情况

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