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Updated: Sep 20, 2025

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通过cryo-EM可视化的Lis1激活dynein的多个步骤

Agnieszka A Kendrick1,2, Kendrick H V Nguyen3, Wen Ma4

  • 1Salk Institute for Biological Studies, La Jolla, CA, USA. akendrick@salk.edu.

Nature structural & molecular biology
|May 23, 2025
PubMed
概括

Lis1通过缓解自身抑制,促进运动组合和运动性来激活细胞质dynein-1 (dynein). 这项研究揭示了dynein激活中的新型中间状态,促进了对这种必不可少的分子电机的理解.

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In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
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