"放射性治疗低风险儿科甲状腺癌:通用标准还是选择性指示?"
Gerdi Tuli1,2, Jessica Munarin3,4, Luisa De Sanctis3,4
1Department of Pediatric Endocrinology, Regina Margherita Children's Hospital, Turin, Italy. gerdi.tuli@unito.it.
Endocrine
|May 23, 2025
概括
对低风险儿科差异化甲状腺癌 (DTC) 的放射性 (RAI) 治疗显示,治疗和未治疗患者之间的疾病持续性没有差异. 建议对这些年轻患者采取个性化的方法.
科学领域:
- 在瘤学瘤学.
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
背景情况:
- 放射性 (RAI) 治疗低风险儿科差异化甲状腺癌 (DTC) 仍然是争论的主题.
- 目前的指导方针缺乏关于在这个特定人群中使用RAI的最终建议.
研究的目的:
- 评价和比较RAI治疗与未治疗的儿童患者与低风险DTC的结果.
- 在年轻DTC患者的RAI治疗中为临床决策提供信息.
主要方法:
- 根据美国甲状腺协会 (ATA) 标准,对儿科低风险DTC患者 (2010-2024) 的回顾性审查.
- 对于DTC>2厘米和/或淋巴结卷入,进行RAI治疗.
- 在治疗和未治疗组之间比较细胞学类别,瘤分期和疾病持续性/复发性.
主要成果:
- 50%的队列 (7/14) 接受了RAI治疗.
- 与未接受治疗的患者相比,RAI治疗的患者显示TIR5细胞学 (71.4%) 和T2阶段 (85.7%) 的患病率更高.
- 在RAI治疗和未治疗组之间,没有观察到疾病持续或复发的显著差异.
结论:
- 在低风险的儿科DTC患者中,RAI治疗没有在疾病持续性或复发方面显示出优异的结果.
- 建议采用个别案例的方法,考虑个体患者的因素,以管理低风险的儿科DTC.
- 对所有儿科DTC患者的RAI绝对建议可能不合适.
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