慢性病患者中性粒细胞功能:系统性审查和元分析
Jane Sophie Lauxen1, Sonja Vondenhoff1, Carolina Victoria Cruz Junho1
1Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.
Acta physiologica (Oxford, England)
|May 24, 2025
概括
在慢性病 (CKD) 患者,特别是血液透析患者中,中性粒细胞功能发生改变. 中性粒细胞中活性氧物种 (ROS) 生产和脱粒的增加可能会导致CKD的心血管风险.
科学领域:
- 免疫学 免疫学 免疫学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管医学 心血管医学
背景情况:
- 患有慢性病 (CKD) 的患者面临心血管疾病 (CVD) 风险升高.
- 中性粒细胞与动脉样硬化和心血管疾病的发病有关.
- 这项研究调查了CKD患者中性粒细胞的功能.
研究的目的:
- 系统地审查和对CKD患者中性粒细胞功能进行元分析.
- 为了比较CKD患者和健康对照者的中性粒细胞功能.
- 探索中性粒细胞功能的改变与CKD中心血管风险之间的关系.
主要方法:
- 对CKD患者中性粒细胞功能研究的系统审查与对照,遵守PRISMA指南.
- 在PubMed和Web of Science数据库中进行的搜索.
- 透析中的CKD患者的活性氧物种 (ROS) 生产的元分析,有偏差风险评估.
主要成果:
- 包括92项研究,其中18项在元分析中;注意到高异质性.
- 接受血液透析的CKD患者表现出减少的细胞化,增加的脱粒化和更高的基底ROS产生.
- 没有透析的CKD患者和腹腔透析的患者在很大程度上没有改变细胞和基底ROS.
结论:
- 血液透析相关的CKD患者表现出增加的中性粒细胞脱粒和基底ROS形成.
- 这些中性粒细胞的变化可能会导致CKD中心血管风险增加.
- 进一步的研究应该检查中性粒细胞在CKD阶段和有关心血管结果的并发症中的活性.
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