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血calprotectin和髓氧化酶作为炎症性肠病中的生物标志物
Duo Hou1, Akhilesh Swaminathan1,2, Grace M Borichevsky3
1Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand.
血髓氧化酶 (pMPO) 显示出作为炎症性肠病 (IBD) 活动的血液生物标志物具有前途,特别是在性结肠炎 (UC) 中. 将pMPO与C反应蛋白 (CRP) 结合起来,可以提高区分活跃IBD和静止疾病的能力.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 临床诊断 临床诊断 临床诊断
- 生物标志物发现发现
背景情况:
- 炎症性肠病 (IBD) 的特点是经常出现的肠道炎症,需要持续监测.
- 现有的疾病活动测量可能具有侵入性或缺乏敏感性.
- 像血髓氧化酶 (pMPO) 和血calprotectin (pCal) 这样的中性粒细胞衍生的蛋白质是潜在的炎症生物标志物.
研究的目的:
- 评估血髓氧化酶 (pMPO) 和血calprotectin (pCal) 与已确定的IBD活性指标的相关性.
- 评估这些血生物标志物的诊断实用性,以识别在胆管结肠镜检查期间的活跃IBD.
主要方法:
- 对接受大肠结肠镜检查的成年IBD患者进行前性研究.
- 收集的血液样本用于pMPO,pCal和C反应蛋白 (CRP) 水平.
- 使用SES-CD (克罗恩病) 和UCEIS (性结肠炎) 评估内镜疾病活动.
- 使用斯皮尔曼等级分析相关性,并通过AUROC曲线和后勤回归评估诊断准确性.
主要成果:
- 与克罗恩病 (CD) 相比,血生物标志物在识别活性性结肠炎 (UC) 中的准确性更高.
- 与单独使用CRP相比,pMPO和CRP的组合显著改善了活性IBD的歧视 (AUROC 0.73与0.70).
- 升高的pMPO (>13.86 ng/mL) 和pCal (>961.72 ng/mL) 水平与活跃UC的几率增加有关.
结论:
- 血髓氧化酶 (pMPO) 是一个有前途的基于血液的生物标志物,用于评估IBD活性,特别是在UC.
- 联合使用pMPO和CRP可以提高诊断准确度,使IBD从活跃到静止区分开来.
- 这些发现表明pMPO可能是IBD管理的宝贵非侵入性工具.
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