遗传学上困惑的个人和法医识别:对当前和新兴解决方案的审查
Hirak Ranjan Dash1,2, Anubhuti Patel3
1Department of Forensic Science, National Forensic Sciences University, Delhi Campus, New Delhi, 110085, India. hirakdash@gmail.com.
International journal of legal medicine
|May 24, 2025
概括
使用捐赠性子细胞的辅助生殖技术 (ART) 是常见的,但对法医识别构成挑战. 需要新的方法来识别通过性质细胞捐赠受孕的个体.
科学领域:
- 生殖医学 生殖医学
- 法医遗传学 法医遗传学
背景情况:
- 不孕率上升和延迟生育增加了对使用捐赠性球体的辅助生殖技术 (ART) 的需求.
- 越来越多的社会对不同家庭的接受以及生殖医学的进步进一步推动了ART的使用.
- 越来越多的通过性器捐赠受孕的个体对传统的法医识别提出了挑战.
研究的目的:
- 评估传统的法医遗传学方法的有效性,以识别通过伴生体捐赠受孕的个体.
- 探索新兴的法医学识别在捐赠者怀孕的群体的方法.
主要方法:
- 审查传统的法医遗传分析 (STR,各种DNA类型的SNP分析).
- 对单体和双体捐赠性质组病例以及线粒体替代疗法的局限性评估.
- 探索新的方法:法医遗传谱系,DNA甲基化和微生物组分析.
主要成果:
- 传统的法医遗传方法 (STR,SNP) 在识别捐赠者怀孕的个体方面具有有限的有效性,特别是在双性子捐赠的情况下.
- 现有的方法对于复杂的病例,如线粒体替代疗法,是不够的.
- 新兴技术显示出希望,但需要进一步验证和标准化.
结论:
- 广泛使用ART需要先进的法医识别策略来识别捐赠者怀孕的个体.
- 诸如遗传谱系学和DNA甲基化等新的方法提供了潜在的解决方案.
- 进一步的研究和标准化对于实施这些新的法医工具至关重要.
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